Dendritic spine geometry, spine apparatus organization: spatiotemporal Ca dynamics (Bell et al 2019)

" ... we systematically investigated the relationship between the shape and size of both the spine head and spine apparatus, a specialized endoplasmic reticulum compartment within the spine head, in modulating rapid calcium dynamics using mathematical modeling. ..."

Model Type: Synapse

Currents: I Calcium; I K

Receptors: NMDA

Model Concept(s): Reaction-diffusion; Calcium dynamics; Signaling pathways

Simulation Environment: COMSOL (web link to model)

Implementer(s): Bell, Miriam

References:

Bell M, Bartol T, Sejnowski T, Rangamani P. (2019). Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. The Journal of general physiology. 151 [PubMed]