"The anesthetic propofol elicits many different spectral properties on the EEG, including alpha oscillations (8-12 Hz), Slow Wave Oscillations (SWO, 0.1-1.5 Hz), and dose-dependent phase-amplitude coupling (PAC) between alpha and SWO. Propofol is known to increase GABAA inhibition and decrease H-current strength, but how it generates these rhythms and their interactions is still unknown. To investigate both generation of the alpha rhythm and its PAC to SWO, we simulate a Hodgkin-Huxley network model of a hyperpolarized thalamus and corticothalamic inputs. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus
Cell Type(s): Hodgkin-Huxley neuron
Currents: I Potassium; I h; I Na,t; I Calcium
Transmitters: Gaba
Model Concept(s): Action Potentials; Oscillations; Activity Patterns
Simulation Environment: DynaSim
References:
Soplata AE et al. (2017). Thalamocortical control of propofol phase-amplitude coupling. PLoS computational biology. 13 [PubMed]