Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)

The periaxonal space in myelinated axons is conductive (~50 ohm cm). Together with a rapidly charging myelin sheath and relatively sealed paranodes, periaxonal conduction shapes the saltating voltage profiles of transaxonal (Vm), transmyelin (Vmy) and transfibre (Vmym) potentials. This model exemplifies double cable saltatory conduction across both time and space, and is the same cell (#6) as seen in Movie S4 of Cohen et al. 2020. This model version allows one to visualize and manipulate the controlling parameters of a propagating action potential. Further notes: The corresponding potentials in NEURON to those named above are v, vext (or vext[0]) and v+vext, respectively. The loaded biophysical parameters were those optimized for this cell (Cohen et al. 2020).

Model Type: Axon; Channel/Receptor; Dendrite; Extracellular; Glia; Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Myelinated neuron

Currents: Ca pump; I Calcium; I h; I K,Ca; I K,leak; I L high threshold; I T low threshold; I M; I Na,p; I Na,t; I Sodium; I Potassium

Model Concept(s): Action Potentials; Active Dendrites; Axonal Action Potentials; Conductance distributions; Conductances estimation; Detailed Neuronal Models; Electrotonus; Extracellular Fields; Membrane Properties; Multiple sclerosis; Parameter sensitivity; Double cable

Simulation Environment: NEURON

Implementer(s): Cohen, Charles CH [c.cohen at]; Kole, Maarten [m.kole at]


Cohen CCH et al. (2020). Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit Cell.

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