Healthy and Epileptic Hippocampal Circuit (Aussel et al 2022)

This model aims at reproducing healthy and epileptic hippocampal oscillations, and includes modeling of the sleep-wake cycle. It was used to study theta-nested gamma oscillations, sharp-wave ripple complexes,

Model Type: Realistic Network

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hodgkin-Huxley neuron

Model Concept(s): Epilepsy; Sleep-Wake transition

Simulation Environment: Brian 2

Implementer(s): Aussel, Amélie [amelie.aussel at loria.fr]

References:

Aussel A et al. (2022). Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations Journal of computational neuroscience. 50 [PubMed]