The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. To study the mechanisms through which these neurons integrate complex input patterns, a new set of models were developed using the latest experimental information and a genetic algorithm approach to fit the maximum ionic channel conductances. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum golgi cell
Currents: I Sodium
Model Concept(s): Action Potential Initiation; Neurotransmitter dynamics; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it]
References:
Masoli S, Ottaviani A, Casali S, D'Angelo E. (2020). Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS computational biology. 16 [PubMed]