Locus Coeruleus blocking model (Chowdhury et al.)

"... Here, we show that Locus Coeruleus (LC) cells projecting to dCA1 have a key permissive role in contextual memory linking, without affecting contextual memory formation, and that this effect is mediated by dopamine. Additionally, we found that LC to dCA1 projecting neurons modulate the excitability of dCA1 neurons, and the extent of overlap between dCA1 memory ensembles, as well as the stability of coactivity patterns within these ensembles..."

Model Type: Spiking neural network; Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Abstract integrate-and-fire neuron

Receptors: AMPA; NMDA; Gaba

Model Concept(s): Long-term Synaptic Plasticity; Synaptic Tagging and Capture; Hebbian plasticity; Calcium dynamics; Excitability

Simulation Environment: C or C++ program; Python

Implementer(s): Kastellakis, George [gkastel at]


Chowdhury A et al. (2022). A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking Neuron. 110 [PubMed]

Kastellakis G, Silva AJ, Poirazi P. (2016). Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell reports. 17 [PubMed]

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