A modified Morris-Lecar with TRPC4 & GIRK (Tian et al. 2022)

Simulates differential activation of TRPC4 and GIRK channel to reproduce various spiking patterns underlying Gq/11–Gi/o coincidence signals. The attached code reproduces Fig.5B-F in Tian et al. 2022. Please see readme.txt to get started.

Model Type: Channel/Receptor

Cell Type(s): Abstract Morris-Lecar neuron

Currents: I_AHP; I CAN; I Calcium

Model Concept(s): Bursting; Action Potentials; Signaling pathways; Activity Patterns

Simulation Environment: MATLAB

Implementer(s): Yang, Jane


Tian J et al. (). TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11–Gi/o coincidence signals of variable strengths PNAS.

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