Simulates differential activation of TRPC4 and GIRK channel to reproduce various spiking patterns underlying Gq/11–Gi/o coincidence signals. The attached code reproduces Fig.5B-F in Tian et al. 2022. Please see readme.txt to get started.
Model Type: Channel/Receptor
Cell Type(s): Abstract Morris-Lecar neuron
Currents: I_AHP; I CAN; I Calcium
Model Concept(s): Bursting; Action Potentials; Signaling pathways; Activity Patterns
Simulation Environment: MATLAB
Implementer(s): Yang, Jane
References:
Tian J et al. (). TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11–Gi/o coincidence signals of variable strengths PNAS.