Integrated Oscillator Model for pancreatic islet beta-cells (Marinelli et al., 2022)


This version of the Integrated Oscillator Model for pancreatic beta-cells includes variables for oxidative phosphorylation, as well as glycolysis, electrical activity, and calcium dynamics.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Pancreatic Beta Cell

Currents: ATP-senstive potassium current

Model Concept(s): Bursting

Simulation Environment: XPPAUT

Implementer(s): Bertram, Richard [rbertram at fsu.edu]

References:

Marinelli I et al. (2022). Oscillations in K(ATP) Conductance Drive Slow Calcium Oscillations in Pancreatic Beta-Cells Biophysical journal. 121 [PubMed]

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