Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Aplysia cultured neuron

Currents: I Na,t; I K

Model Concept(s): Activity Patterns; Bursting; Oscillations; Action Potentials; Invertebrate

Simulation Environment: SNNAP

Implementer(s): Komendantov, Alexander O [akomenda at]; Kononenko, Nikolai I [nik137 at]


Komendantov AO, Kononenko NI. (2000). Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology. 32

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.