A set of models is presented based on 2 related parameterizations to reproduce spiking and bursting behavior of multiple types of cortical neurons and thalamic neurons. These models combine the biologically plausibility of Hodgkin Huxley-type dynamics and the computational efficiency of integrate-and-fire neurons. Using these model, one can simulate tens of thousands of spiking cortical neurons in real time (1 ms resolution) using a desktop PC.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Abstract Izhikevich neuron
Model Concept(s): Action Potential Initiation; Activity Patterns; Parameter Fitting; Simplified Models; Tutorial/Teaching; Action Potentials
Simulation Environment: NEURON; MATLAB
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Dura-Bernal, Salvador [salvadordura at gmail.com]
References:
Izhikevich EM. (2007). Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting.
Izhikevich EM. (2004). Which model to use for cortical spiking neurons? IEEE transactions on neural networks. 15 [PubMed]
Izhikevich EM. (2003). Simple model of spiking neurons. IEEE transactions on neural networks. 14 [PubMed]