Paired turbulence and light effect on calcium increase in Hermissenda (Blackwell 2004)

The sea slug Hermissenda learns to associate light and hair cell stimulation, but not when the stimuli are temporally uncorrelated...These issues were addressed using a multi-compartmental computer model of phototransduction, calcium dynamics, and ionic currents of the Hermissenda photoreceptor...simulations show that a potassium leak channel, which closes with an increase in calcium, is required to produce both the untrained LLD and the enhanced LLD due to the decrease in voltage dependent potassium currents.

Model Type: Neuron or other electrically excitable cell; Electrogenic pump

Cell Type(s): Hermissenda photoreceptor Type B

Currents: I A; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium

Receptors: GabaA; GabaB; IP3

Transmitters: Gaba

Model Concept(s): Temporal Pattern Generation; Invertebrate; Signaling pathways; Calcium dynamics

Simulation Environment: Chemesis

Implementer(s): Blackwell, Avrama [avrama at]


Blackwell KT. (2004). Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda. Journal of computational neuroscience. 17 [PubMed]

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