This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata.
Model Type: Dendrite
Cell Type(s): Crayfish identified nonspiking interneuron
Currents: I A; I K; I Potassium
Model Concept(s): Influence of Dendritic Geometry; Invertebrate; Synaptic Integration
Simulation Environment: GENESIS
Implementer(s): Takahata, Masakazu [takahata at sci.hokudai.ac.jp]
References:
Takashima A, Hikosaka R, Takahata M. (2006). Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. Journal of neurophysiology. 96 [PubMed]
Takahata M, Takashima A, Hikosaka R. (2000). Information processing by nonspiking interneurons: passive and active properties of dendritic membrane determine synaptic integration. Bio Systems. 58 [PubMed]