Classic model developed by Petter Getting of the 3-cell core CPG (DSI, C2, and VSI-B) mediating escape swimming in Tritonia diomedea. Cells use a hybrid integrate-and-fire scheme pioneered by Peter Getting. Each model cell is reconstructed from extensive physiological measurements to precisely mimic I-F curves, synaptic waveforms, and functional connectivity. **However, continued physiological measurements show that Getting may have inadvertently incorporated modulatory and or polysynaptic effects -- the properties of this model do *not* match physiological measurements in rested preparations.** This simulation reconstructs the Getting model as reported in: Getting (1989) 'Reconstruction of small neural networks' In Methods in Neural Modeling, 1st ed, p. 171-196. See also, an earlier version of this model reported in Getting (1983). Every attempt has been made to replicate the 1989 model as precisely as possible.
Model Type: Realistic Network
Region(s) or Organism(s): Tritonia
Cell Type(s): Tritonia swim interneuron dorsal; Tritonia cerebral cell; Tritonia swim interneuron ventral
Currents: I A
Model Concept(s): Bursting; Oscillations; Invertebrate
Simulation Environment: NEURON
Implementer(s): Calin-Jageman, Robert [rcalinjageman at gsu dot edu]
References:
Getting PA. (1989). Reconstruction of small neural networks. Methods in Neuronal Modeling: From Synapses to Networks..
Getting PA. (1983). Mechanisms of pattern generation underlying swimming in Tritonia. II. Network reconstruction. Journal of neurophysiology. 49 [PubMed]