Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)

This model shows how backpropagating action potentials in the long lateral dendrites of mitral cells, together with granule cell actions on mitral cells within narrow columns forming glomerular units, can provide a mechanism to activate strong local inhibition between arbitrarily distant mitral cells. The simulations predict a new role for the dendrodendritic synapses in the multicolumnar organization of the granule cells.

Model Type: Realistic Network

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell

Currents: I Na,t; I A; I K

Receptors: AMPA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Pattern Recognition; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Olfaction

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Migliore M, Shepherd GM. (2008). Dendritic action potentials connect distributed dendrodendritic microcircuits. Journal of computational neuroscience. 24 [PubMed]