Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).

Model Type: Realistic Network

Region(s) or Organism(s): Thalamus

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell

Currents: I T low threshold

Receptors: GabaA; Glutamate

Transmitters: Gaba; Glutamate

Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]

References:

Lytton WW, Contreras D, Destexhe A, Steriade M. (1997). Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. Journal of neurophysiology. 77 [PubMed]