Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)


In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,t; I K; I M; I h

Genes: HCN1; HCN2

Model Concept(s): Action Potential Initiation; Active Dendrites; Axonal Action Potentials; Action Potentials

Simulation Environment: NEURON

Implementer(s): Kole, Maarten [m.kole at nin.knaw.nl]

References:

Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience 11 [PubMed]