"... Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes. Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli. This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses. ... the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. ..."
Model Type: Synapse
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Cerebellum Purkinje GABA cell; Auditory nerve
Currents: I Calcium
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Synaptic Plasticity; Facilitation; Depression; Calcium dynamics
Simulation Environment: MATLAB; Simulink
Implementer(s): Lee, Chuang-Chung [chchlee at alum.mit.edu]; Anton, Mihai [mianton at mit.edu]; Poon, Chi-Sang [cpoon at mit.edu]; McRae, Gregory [mcrae at mit.edu]
References:
Lee CC, Anton M, Poon CS, McRae GJ. (2009). A kinetic model unifying presynaptic short-term facilitation and depression. Journal of computational neuroscience. 26 [PubMed]