"We investigated by a computational model of the basal ganglia the different network effects of deep brain stimulation (DBS) for Parkinson’s disease (PD) in different target sites in the subthalamic nucleus (STN), the globus pallidus pars interna (GPi), and the globus pallidus pars externa (GPe). A cellular-based model of the basal ganglia system (BGS), based on the model proposed by Rubin and Terman (J Comput Neurosci 16:211–235, 2004), was developed. ... Our results suggest that DBS in the STN could functionally restore the TC relay activity, while DBS in the GPe and in the GPi could functionally over-activate and inhibit it, respectively. Our results are consistent with the experimental and the clinical evidences on the network effects of DBS."
Model Type: Realistic Network; Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex; Thalamus; Basal ganglia; Subthalamic Nucleus
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Subthalamus nucleus projection neuron; Globus pallidus neuron
Currents: I Na,t; I T low threshold; I K; I Calcium
Model Concept(s): Activity Patterns; Parkinson's; Deep brain stimulation
Simulation Environment: MATLAB
Implementer(s): Pirini, Marco [marco.pirini at unibo.it]
References:
Pirini M, Rocchi L, Sensi M, Chiari L. (2009). A computational modelling approach to investigate different targets in deep brain stimulation for Parkinson's disease. Journal of computational neuroscience. 26 [PubMed]