"… Recently, a lot of interest has been devoted to desynchronizing delayed feedback deep brain stimulation (DBS). ... This study explores the action of delayed feedback stimulation on partially synchronized oscillatory dynamics, similar to what one observes experimentally in parkinsonian patients. …" Implemented by Andrey Dovzhenok, to whom questions should be addressed.
Model Type: Realistic Network
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Subthalamus nucleus projection neuron; Globus pallidus neuron
Currents: I Na,t; I T low threshold; I K; I_AHP; I Ca,p
Model Concept(s): Synchronization; Parkinson's; Deep brain stimulation
Simulation Environment: XPPAUT; MATLAB
Implementer(s): Dovzhenok, Andrey [andrey.dovzhenok at uc.edu]
References:
Dovzhenok A, Park C, Worth RM, Rubchinsky LL. (2013). Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PloS one. 8 [PubMed]