This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Model Type: Realistic Network; Extracellular
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron
Model Concept(s): Activity Patterns; Oscillations; Pathophysiology; Epilepsy; Brain Rhythms
Simulation Environment: NEURON; Python
Implementer(s): Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]; Sanjay, M [msanjaycmc at gmail.com]
Sanjay M, Neymotin SA, Krothapalli SB. (2015). Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25 [PubMed]