The (Wang 1994) papers model was replicated in python by (Detorakis 2016). "The model is conductance-based and takes advantage of the interplay between a T-type calcium current and a non-specific cation sag current and thus, it is able to generate spindle and delta rhythms." The model also generates intermittent phase locking, non periodic firing, bursts, and tonic spike patterns.
Region(s) or Organism(s): Thalamus
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell
Currents: I Calcium
Model Concept(s): Bursting; Action Potentials; Bifurcation; Calcium dynamics; Sleep; Activity Patterns; Oscillations; Spindles
Simulation Environment: Python (web link to model)
Implementer(s): Detorakis, Georgios [gdetorak at uci.edu]
References:
Wang XJ. (1994). Multiple dynamical modes of thalamic relay neurons: rhythmic bursting and intermittent phase-locking. Neuroscience. 59 [PubMed]
Detorakis GI. (2016). [Re] Multiple dynamical modes of thalamic relay neurons: rhythmic bursting and intermittent phase-locking ReScience. 2(1)