While many theoretical models of neural dynamics during sleep exist, few include the effects of neuromodulators on sleep oscillations and describe transitions between different states of vigilance. Here, we ported an established thalamocortical network model (https://doi.org/10.7554/eLife.18607) from C++ to NEURON. This model, which includes a biophysically realistic description of intrinsic and synaptic channels, allows for testing the effects of different neuromodulators, intrinsic cell properties, and synaptic connectivity on neural dynamics during sleep.
Model Type: Realistic Network
Region(s) or Organism(s): Neocortex; Thalamus
Cell Type(s):
Currents: I K; I K,Ca; I K,leak; I Na,p; I T low threshold; I h
Receptors:
Genes:
Transmitters: Acetylcholine; Gaba; Glutamate; Histamine
Model Concept(s):
Simulation Environment: NEURON
Implementer(s): Fink, Christian G. [finkt at gonzaga.edu]
References:
Krishnan GP et al. (2016). Cellular and neurochemical basis of sleep stages in the thalamocortical network. eLife. 5 [PubMed]