"The analysis of BC inhibition of PCs was extended over a broad parameter space using accurate multi-compartmental computational models. During pf bursts, the BC reduced the PC response at low-frequency, while SCs did it at high-frequency. BC filtering was explained by the engagement of HCN1 channels, which activated slowly during low-frequency BC-PC GABAergic transmission. The increase of input conductance caused by HCN1 channels in the PC soma, by shunting excitatory currents elicited by pfs and travelling toward the axon initial segment (AIS), reduced the PC output frequency."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Cerebellum
Cell Type(s): Hodgkin-Huxley neuron
Currents:
Receptors: AMPA
Genes:
Model Concept(s): Action Potentials; Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it]; Rizza, Martina Francesca
References:
Masoli S et al. (2025). Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission. Scientific reports. 15 [PubMed]