Neural mass model of the neocortex under sleep regulation (Costa et al 2016)

This model generates typical human EEG patterns of sleep stages N2/N3 as well as wakefulness and REM. It further contains a sleep regulatory component, that lets the model transition between those stages independently

Model Type: Neural mass

Region(s) or Organism(s): Brainstem; Neocortex

Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Neocortex layer 2-3 interneuron

Currents: I_K,Na; Na/K pump

Receptors: AMPA; Gaba; Cholinergic Receptors

Transmitters: Acetylcholine; Norephinephrine; Gaba

Model Concept(s): Simplified Models; Temporal Pattern Generation; Sleep; Activity Patterns; Oscillations; Bifurcation; Electrical-chemical; Neuromodulation

Simulation Environment: Network; C or C++ program (web link to model); MATLAB (web link to model)

Implementer(s): Schellenberger Costa, Michael [mschellenbergercosta at gmail.com]

References:

Weigenand A, Schellenberger Costa M, Ngo HV, Claussen JC, Martinetz T. (2014). Characterization of K-complexes and slow wave activity in a neural mass model. PLoS computational biology. 10 [PubMed]

Costa MS, Born J, Claussen JC, Martinetz T. (2016). Modeling the effect of sleep regulation on a neural mass model. Journal of computational neuroscience. 41 [PubMed]