This model consists of an inhibitory loop combining the projections from GPe neurons back to the striatum (shown experimentally to predominantly affect fast spiking interneurons, FSIs), together with the coupling from FSIs to medium spiny neurons (MSNs) in the striatum, along with the projections from MSNs to GPe. All models are in the Hodgkin-Huxley formalism, adapted from previously published models for each cell type. The connected circuit produces irregular activity under control conditions, but increasing FSI-to-MSN connectivity as observed experimentally under dopamine depletion yields exaggerated beta oscillations and synchrony. Additional mechanistic aspects are also explored.
Model Type: Neuron or other electrically excitable cell; Realistic Network
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Globus pallidus neuron; Hodgkin-Huxley neuron; Neostriatum fast spiking interneuron; Neostriatum spiny neuron
Model Concept(s): Oscillations; Synchronization
Simulation Environment: XPPAUT
Implementer(s): Rubin, Jonathan E [jonrubin at pitt.edu]; Whalen, Timothy C [timcwhalen at gmail.com]; Corbit, Victoria L [vic22 at pitt.edu]
References:
Corbit VL et al. (2016). Pallidostriatal Projections Promote ß Oscillations in a Dopamine-Depleted Biophysical Network Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]