We reconstructed the GGN (giant GABAergic neuron) morphology from 3D confocal image stack, and built a passive model based on the morphology to study signal attenuation across this giant neuron. In order to study the effect of feedback inhibition from this cell on odor information processing, we created a model of the olfactory network in the locust mushroom body with 50,000 KCs (Kenyon cell) reciprocally connected to this neuron. Finally, we added a model of the IG (Inhibitor of GGN) to reproduce in vivo odor responses in GGN.
Model Type: Neuron or other electrically excitable cell; Realistic Network
Region(s) or Organism(s): Mushroom body; Locust
Cell Type(s): Honeybee kenyon cell; Abstract Izhikevich neuron; Locust Giant GABAergic Neuron (GGN)
Transmitters: Gaba; Acetylcholine
Model Concept(s): Olfaction; Sensory processing
Simulation Environment: NEURON
Implementer(s): Ray, Subhasis [ray.subhasis at gmail.com]
References:
Ray S, Aldworth ZN, Stopfer MA. (2020). Feedback inhibition and its control in an insect olfactory circuit. eLife. 9 [PubMed]