The code is an extension of the thalamocortical model of Traub et al. (2005) J Neurophysiol. It is here applied to an in vitro model of the electrodecremental response seen in the EEG of children with infantile spasms (West syndrome)
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus; Neocortex
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex layer 4 pyramidal cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiny stellate cell
Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow
Model Concept(s): Brain Rhythms; Epilepsy
Simulation Environment: FORTRAN
Implementer(s): Traub, Roger D [rtraub at us.ibm.com]
References:
Traub RD et al. (2020). Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms. Reviews in the neurosciences 31 [PubMed]
Hall S et al. (2015). Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 35 [PubMed]
Carracedo LM et al. (2013). A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 [PubMed]