This model is used to explain how chronic stimulation of pancreatic beta-cells can lead to compensation that restores calcium oscillations and electrical bursting.
Model Type: Neuron or other electrically excitable cell
Currents: I K; I Calcium; I K,Ca
Model Concept(s): Bursting; Calcium dynamics
Simulation Environment: XPPAUT
References:
Law NC et al. (2020). Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro. American journal of physiology. Endocrinology and metabolism. 318 [PubMed]