Using kinetic data from three different K+ currents in acutely isolated neurons, a single electrical compartment model representing the soma of a ventral cochlear nucleus (VCN) neuron was created. The K+ currents include a fast transient current (IA), a slow-inactivating low-threshold current (ILT), and a noninactivating high-threshold current (IHT). The model also includes a fast-inactivating Na+ current, a hyperpolarization-activated cation current (Ih), and 1-50 auditory nerve synapses. With this model, the role IA, ILT, and IHT play in shaping the discharge patterns of VCN cells is explored. Simulation results indicate these currents have specific roles in shaping the firing patterns of stellate and bushy CN cells. (see readme.txt and the papers, esp 2003c, for details). Any questions regarding these implementations should be directed to: pmanis@med.unc.edu 2 April 2004 Paul B Manis, Ph.D.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cochlear nucleus bushy GLU cell; CN stellate cell
Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I Sodium; I Potassium
Model Concept(s): Temporal Pattern Generation; Action Potentials; Audition
Simulation Environment: NEURON
Implementer(s): Manis, Paul B [PManis at med.unc.edu]
References:
Rothman JS, Manis PB. (2003). The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons. Journal of neurophysiology. 89 [PubMed]
Rothman JS, Manis PB. (2003). Kinetic analyses of three distinct potassium conductances in ventral cochlear nucleus neurons. Journal of neurophysiology. 89 [PubMed]
Rothman JS, Manis PB. (2003). Differential expression of three distinct potassium currents in the ventral cochlear nucleus. Journal of neurophysiology. 89 [PubMed]