Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron

Currents: I Na,t; I K

Receptors: AMPA

Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction

Simulation Environment: NEURON

Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]

References:

Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J. (2002). Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. Journal of neurophysiology. 88 [PubMed]