A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. ... The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics. See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Heart cell; Cardiac ventricular cell
Currents: I Na,t; I L high threshold; I K; I K,leak; I_Ks
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease
Simulation Environment: C or C++ program (web link to model)
References:
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