Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++)

A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. ... The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics. See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Heart cell; Cardiac ventricular cell

Currents: I Na,t; I L high threshold; I K; I K,leak; I_Ks

Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease

Simulation Environment: C or C++ program (web link to model)


Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research 77 [PubMed]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal 68 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research 74 [PubMed]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 99 [PubMed]

Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research 68 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research 74 [PubMed]

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research 35 [PubMed]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research 42 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature 400 [PubMed]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation 101 [PubMed]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal 78 [PubMed]

Wang YJ, Sung RJ, Lin MW, Wu SN. (2006). Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. The Journal of membrane biology 213 [PubMed]