Tutorial simulation of a cerebellar Purkinje cell. This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that you have a basic knowledge of the Purkinje cell and its synaptic inputs. It gives visual insight in how different properties as concentrations and channel conductances vary and interact within a real Purkinje cell.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cerebellum Purkinje GABA cell
Currents: I Na,p; I Na,t; I T low threshold; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Tutorial/Teaching; Synaptic Integration
Simulation Environment: GENESIS
Implementer(s): Cornelis, Hugo [hugo at bbf.uia.ac.be]; Airong, Dong [tard at fimmu.com]
References:
De Schutter E, Bower JM. (1994). An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. Journal of neurophysiology 71 [PubMed]
De Schutter E, Bower JM. (1994). An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. Journal of neurophysiology 71 [PubMed]
Staub C, De Schutter E, Knöpfel T. (1994). Voltage-imaging and simulation of effects of voltage- and agonist-activated conductances on soma-dendritic voltage coupling in cerebellar Purkinje cells. Journal of computational neuroscience 1 [PubMed]
De Schutter E, Bower JM. (1994). Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proceedings of the National Academy of Sciences of the United States of America 91 [PubMed]
De Schutter E. (1998). Dendritic voltage and calcium-gated channels amplify the variability of postsynaptic responses in a Purkinje cell model. Journal of neurophysiology 80 [PubMed]
Jaeger D, De Schutter E, Bower JM. (1997). The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience 17 [PubMed]
de Schutter E. (1994). Modelling the cerebellar Purkinje cell: experiments in computo. Progress in brain research 102 [PubMed]
De Schutter E. (1997). A new functional role for cerebellar long-term depression. Progress in brain research 114 [PubMed]
Steuber V et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54 [PubMed]