This a conductance-based model of a rod photoreceptor cell based on other modeling works (Barnes and Hille 1989 and Publio et al. 2006 and Kourennyi and Liu et al. 2004 ). In this model four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca) was used. The model accurately reproduces the rod response when stimulated with a simulated photocurrent signal. We can show the effect of nonselective cation channel. The absence of this channel cause increasing the peak amplitude and the time to reach the peak of voltage response and absence of transient mode in this response.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Retina photoreceptor cone GLU cell
Currents: I Cl,Ca; I K,Ca; I Calcium; I Potassium
Model Concept(s): Ion Channel Kinetics; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Shahali, Mahboubeh [shahali222 at yahoo.com]
References:
Barnes S, Hille B. (1989). Ionic channels of the inner segment of tiger salamander cone photoreceptors. The Journal of general physiology. 94 [PubMed]
Kourennyi DE et al. (2004). Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide. Journal of neurophysiology. 92 [PubMed]
Liu XD, Kourennyi DE. (2004). Effects of tetraethylammonium on Kx channels and simulated light response in rod photoreceptors. Annals of biomedical engineering. 32 [PubMed]
Publio R, Oliveira RF, Roque AC. (2006). A realistic model of rod photoreceptor for use in a retina network model Neurocomputing. 69