Model of DARPP-32 phosphorylation in striatal medium spiny neurons (Lindskog et al. 2006)

The work describes a model of how transient calcium and dopamine inputs might affect phosphorylation of DARPP-32 in the medium spiny neurons in the striatum. The model is relevant for understanding both the "three-factor rule" for synaptic plasticity in corticostriatal synapses, and also for relating reinforcement learning theories to biology.

Model Type: Molecular Network

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Currents: I Calcium

Receptors: D1; D2

Genes: D1 DRD1A; D2 DRD2

Transmitters: Dopamine

Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways; Reinforcement Learning

Simulation Environment: XPPAUT

References:

Lindskog M, Kim M, Wikström MA, Blackwell KT, Kotaleski JH. (2006). Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS computational biology. 2 [PubMed]