Presynaptic calcium dynamics at neuromuscular junction (Stockbridge, Moore 1984)

The diffusion of calcium is effectively reduced by the ratio of bound to free calcium. Treating the release magnitude as proportional to the fourth power of calcium concentration next to the membrane gives reasonable facilitation with very little release between spikes.

Model Type: Neuromuscular Junction

Model Concept(s): Simplified Models; Short-term Synaptic Plasticity; Facilitation; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Hines, Michael [Michael.Hines at]


Stockbridge N, Moore JW. (1984). Dynamics of intracellular calcium and its possible relationship to phasic transmitter release and facilitation at the frog neuromuscular junction. The Journal of neuroscience : the official journal of the Society for Neuroscience 4 [PubMed]