"... The model hereby clarifies, for the first time, how the following levels of brain organization coexist to realize cognitive processing properties that regulate fast learning and stable memory of brain representations: single cell properties, such as spiking dynamics, spike-timing-dependent plasticity (STDP), and acetylcholine modulation; detailed laminar thalamic and cortical circuit designs and their interactions; aggregate cell recordings, such as current-source densities and local field potentials; and single cell and large-scale inter-areal oscillations in the gamma and beta frequency domains. ..."
Model Type: Realistic Network
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell
Currents: I Na,t; I T low threshold; I K; I Potassium
Receptors: AMPA; Gaba; Cholinergic Receptors
Model Concept(s): Pattern Recognition; Activity Patterns; Oscillations; Synchronization; Working memory; STDP; Spatial Navigation
Simulation Environment: KInNeSS (web link to model); XML (web link to model); NeuroML (web link to model)
References:
Grossberg S, Versace M. (2008). Spikes, synchrony, and attentive learning by laminar thalamocortical circuits Brain research. 1218 [PubMed]