In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Currents: I Na,t; I K; I M; I h
Model Concept(s): Action Potential Initiation; Active Dendrites; Axonal Action Potentials; Action Potentials
Simulation Environment: NEURON
Implementer(s): Kole, Maarten [m.kole at nin.knaw.nl]
References:
Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience. 11 [PubMed]