Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. ... We also used a simulation model to evaluate intracellular adenosine triphosphate (ATP) and neuroexcitability. ... In the simulation, increased intracellular ATP concentration promoted action potential firing. This finding that rats with DH had more brain damage after SE than rats without diabetes suggests the importance of intensively treating hyperglycemia and seizures in diabetic patients with epilepsy.
Model Type: Realistic Network
Cell Type(s): Hodgkin-Huxley neuron
Currents: ATP-senstive potassium current
Model Concept(s): Action Potentials; Epilepsy
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]
References:
Huang CW, Cheng JT, Tsai JJ, Wu SN, Huang CC. (2009). Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. Neurotoxicity research. 15 [PubMed]