Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus
Simulation Environment: NEURON
Implementer(s): Lytton, William [bill.lytton at downstate.edu]