Mathematical model for windup (Aguiar et al. 2010)


Aguiar P, Sousa M, Lima D. (2010). NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons. Journal of neurophysiology. 104 [PubMed]

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References and models cited by this paper

Ahmadi S et al. (2003). Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine. Science (New York, N.Y.). 300 [PubMed]

Baranauskas G, Nistri A. (1998). Sensitization of pain pathways in the spinal cord: cellular mechanisms. Progress in neurobiology. 54 [PubMed]

Budai D, Larson AA. (1996). Role of substance P in the modulation of C-fiber-evoked responses of spinal dorsal horn neurons. Brain research. 710 [PubMed]

Burnashev N, Zhou Z, Neher E, Sakmann B. (1995). Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. The Journal of physiology. 485 ( Pt 2) [PubMed]

Destexhe A, Babloyantz A, Sejnowski TJ. (1993). Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons. Biophysical journal. 65 [PubMed]

Destexhe A, Contreras D, Sejnowski TJ, Steriade M. (1994). A model of spindle rhythmicity in the isolated thalamic reticular nucleus. Journal of neurophysiology. 72 [PubMed]

Dickenson AH, Sullivan AF. (1987). Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology. 26 [PubMed]

Duggan AW, Riley RC, Mark MA, MacMillan SJ, Schaible HG. (1995). Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anaesthetized spinal cat. Neuroscience. 65 [PubMed]

Fossat P, Sibon I, Le Masson G, Landry M, Nagy F. (2007). L-type calcium channels and NMDA receptors: a determinant duo for short-term nociceptive plasticity. The European journal of neuroscience. 25 [PubMed]

Fuhrmann G, Segev I, Markram H, Tsodyks M. (2002). Coding of temporal information by activity-dependent synapses. Journal of neurophysiology. 87 [PubMed]

Guan Y, Borzan J, Meyer RA, Raja SN. (2006). Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Herrero JF, Laird JM, López-García JA. (2000). Wind-up of spinal cord neurones and pain sensation: much ado about something? Progress in neurobiology. 61 [PubMed]

Hillman P, Wall PD. (1969). Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells. Experimental brain research. 9 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Ito K, Rome C, Bouleau Y, Dulon D. (2002). Substance P mobilizes intracellular calcium and activates a nonselective cation conductance in rat spiral ganglion neurons. The European journal of neuroscience. 16 [PubMed]

Jahr CE, Stevens CF. (1990). A quantitative description of NMDA receptor-channel kinetic behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Li J, Simone DA, Larson AA. (1999). Windup leads to characteristics of central sensitization. Pain. 79 [PubMed]

Liu H, Mantyh PW, Basbaum AI. (1997). NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature. 386 [PubMed]

MENDELL LM, WALL PD. (1965). RESPONSES OF SINGLE DORSAL CORD CELLS TO PERIPHERAL CUTANEOUS UNMYELINATED FIBRES. Nature. 206 [PubMed]

Mantyh PW. (2002). Neurobiology of substance P and the NK1 receptor. The Journal of clinical psychiatry. 63 Suppl 11 [PubMed]

Marvizón JC, Martínez V, Grady EF, Bunnett NW, Mayer EA. (1997). Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

McCormick DA, Huguenard JR. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. Journal of neurophysiology. 68 [PubMed]

Mendell LM. (1966). Physiological properties of unmyelinated fiber projection to the spinal cord. Experimental neurology. 16 [PubMed]

Morisset V, Nagy F. (2000). Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons. The European journal of neuroscience. 12 [PubMed]

Partridge LD, Swandulla D. (1988). Calcium-activated non-specific cation channels. Trends in neurosciences. 11 [PubMed]

Prescott SA, De Koninck Y. (2005). Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Price DD, Hull CD, Buchwald NA. (1971). Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli. Experimental neurology. 33 [PubMed]

Sandkühler J. (2000). Learning and memory in pain pathways. Pain. 88 [PubMed]

Schouenborg J. (1984). Functional and topographical properties of field potentials evoked in rat dorsal horn by cutaneous C-fibre stimulation. The Journal of physiology. 356 [PubMed]

Schouenborg J, Sjölund BH. (1983). Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex. Journal of neurophysiology. 50 [PubMed]

Sivilotti LG, Thompson SW, Woolf CJ. (1993). Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro. Journal of neurophysiology. 69 [PubMed]

Traub RD, Miles R. (1991). Neuronal Networks of the Hippocampus.

Urch CE, Dickenson AH. (2003). Neuronal nitric oxide synthase modulation of dorsal horn neuronal responses in the rat: a developmental study. Developmental neuroscience. 25 [PubMed]

Woolf CJ. (1996). Windup and central sensitization are not equivalent. Pain. 66 [PubMed]

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Conde-Sousa E, Aguiar P. (2013). A working memory model for serial order that stores information in the intrinsic excitability properties of neurons. Journal of computational neuroscience. 35 [PubMed]

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Medlock L et al. (2022). Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]

Sousa M, Szucs P, Lima D, Aguiar P. (2014). The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation. Journal of neurophysiology. 111 [PubMed]

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