In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): GnRH neuron
Model Concept(s): Bursting; Active Dendrites; Action Potentials; Calcium dynamics
Simulation Environment: MATLAB (web link to model)
References:
Csercsik D, Farkas I, Hrabovszky E, Liposits Z. (2012). A simple integrative electrophysiological model of bursting GnRH neurons. Journal of computational neuroscience. 32 [PubMed]