"Selective optogenetic drive of fast-spiking (FS) interneurons (INs) leads to enhanced local field potential (LFP) power across the traditional “gamma” frequency band (20–80 Hz; Cardin et al., 2009). In contrast, drive to regular-spiking (RS) pyramidal cells enhances power at lower frequencies, with a peak at 8 Hz. The first result is consistent with previous computational studies emphasizing the role of FS and the time constant of GABAA synaptic inhibition in gamma rhythmicity. However, the same theoretical models do not typically predict low-frequency LFP enhancement with RS drive. To develop hypotheses as to how the same network can support these contrasting behaviors, we constructed a biophysically principled network model of primary somatosensory neocortex containing FS, RS, and low-threshold spiking (LTS) INs. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron
Currents: I Na,t; I T low threshold; I K; I M; I h; I K,Ca; I Calcium
Model Concept(s): Oscillations; Detailed Neuronal Models; Brain Rhythms; Evoked LFP; Touch
Simulation Environment: NEURON
Implementer(s): Vierling-Claassen, Dorea
References:
Vierling-Claassen D, Cardin JA, Moore CI, Jones SR. (2010). Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons. Frontiers in human neuroscience. 4 [PubMed]