The paper demonstrate a form of graded persistent activity activated by hyperpolarization. This phenomenon is modeled based on a slow calcium regulation of Ih, similar to that introduced earlier for thalamic neurons (see Destexhe et al., J Neurophysiol. 1996). The only difference is that the calcium signal is here provided by the high-threshold calcium current (instead of the low-threshold calcium current in thalamic neurons).
Model Type: Neuron or other electrically excitable cell; Channel/Receptor
Region(s) or Organism(s): Prefrontal cortex (PFC)
Currents: I Na,t; I L high threshold; I K; I M; I h
Model Concept(s): Activity Patterns; Ion Channel Kinetics
Simulation Environment: NEURON
Implementer(s): Skolnick, Yosef [yskolnick at gmail.com]
References:
Winograd M, Destexhe A, Sanchez-Vives MV. (2008). Hyperpolarization-activated graded persistent activity in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]