Nodes of Ranvier with left-shifted Nav channels (Boucher et al. 2012)


Boucher PA, Joós B, Morris CE. (2012). Coupled left-shift of Nav channels: modeling the Na?-loading and dysfunctional excitability of damaged axons. Journal of computational neuroscience. 33 [PubMed]

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References and models cited by this paper

Banderali U, Juranka PF, Clark RB, Giles WR, Morris CE. (2010). Impaired stretch modulation in potentially lethal cardiac sodium channel mutants. Channels (Austin, Tex.). 4 [PubMed]

Beyder A et al. (2010). Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. The Journal of physiology. 588 [PubMed]

Bostock H, Rothwell JC. (1997). Latent addition in motor and sensory fibres of human peripheral nerve. The Journal of physiology. 498 ( Pt 1) [PubMed]

Burbidge SA et al. (2002). Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brain. Brain research. Molecular brain research. 103 [PubMed]

Coggan JS, Ocker GK, Sejnowski TJ, Prescott SA. (2011). Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models. Journal of neural engineering. 8 [PubMed]

Coggan JS, Prescott SA, Bartol TM, Sejnowski TJ. (2010). Imbalance of ionic conductances contributes to diverse symptoms of demyelination. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Devor M. (2009). Ectopic discharge in Abeta afferents as a source of neuropathic pain. Experimental brain research. 196 [PubMed]

Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. (2011). Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC biology. 9 [PubMed]

Finol-Urdaneta RK, McArthur JR, Juranka PF, French RJ, Morris CE. (2010). Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents. Biophysical journal. 98 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Hodgkin AL. (1948). The local electric changes associated with repetitive action in a non-medullated axon. The Journal of physiology. 107 [PubMed]

Izhikevich EM. (2001). Resonate-and-fire neurons. Neural networks : the official journal of the International Neural Network Society. 14 [PubMed]

Kager H, Wadman WJ, Somjen GG. (2000). Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. Journal of neurophysiology. 84 [PubMed]

Kole MH. (2011). First node of Ranvier facilitates high-frequency burst encoding. Neuron. 71 [PubMed]

Kovalsky Y, Amir R, Devor M. (2009). Simulation in sensory neurons reveals a key role for delayed Na+ current in subthreshold oscillations and ectopic discharge: implications for neuropathic pain. Journal of neurophysiology. 102 [PubMed]

Krishnan GP, Bazhenov M. (2011). Ionic dynamics mediate spontaneous termination of seizures and postictal depression state. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Lemieux DR, Roberge FA, Joly D. (1992). Modeling the dynamic features of the electrogenic Na,K pump of cardiac cells. Journal of theoretical biology. 154 [PubMed]

Lorincz A, Nusser Z. (2010). Molecular identity of dendritic voltage-gated sodium channels. Science (New York, N.Y.). 328 [PubMed]

Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. (2010). Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. The Lancet. Neurology. 9 [PubMed]

Maxwell WL. (1996). Histopathological changes at central nodes of Ranvier after stretch-injury. Microscopy research and technique. 34 [PubMed]

Morris C, Lecar H. (1981). Voltage oscillations in the barnacle giant muscle fiber. Biophysical journal. 35 [PubMed]

Morris CE, Boucher PA, Joós B. (2012). Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists? Frontiers in pharmacology. 3 [PubMed]

Ochab-Marcinek A, Schmid G, Goychuk I, Hänggi P. (2009). Noise-assisted spike propagation in myelinated neurons. Physical review. E, Statistical, nonlinear, and soft matter physics. 79 [PubMed]

Prescott SA, De Koninck Y, Sejnowski TJ. (2008). Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS computational biology. 4 [PubMed]

Ross ST, Soltesz I. (2000). Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase. Journal of neurophysiology. 83 [PubMed]

Schafer DP et al. (2009). Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Seifert G et al. (2009). Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Stys PK, Sontheimer H, Ransom BR, Waxman SG. (1993). Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons. Proceedings of the National Academy of Sciences of the United States of America. 90 [PubMed]

Tabarean IV, Juranka P, Morris CE. (1999). Membrane stretch affects gating modes of a skeletal muscle sodium channel. Biophysical journal. 77 [PubMed]

Taddese A, Bean BP. (2002). Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 33 [PubMed]

Thomas EA et al. (2009). Heat opens axon initial segment sodium channels: a febrile seizure mechanism? Annals of neurology. 66 [PubMed]

Volman V, Bazhenov M, Sejnowski TJ. (2011). Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation. Proceedings of the National Academy of Sciences of the United States of America. 108 [PubMed]

Wang JA et al. (2009). Membrane trauma and Na+ leak from Nav1.6 channels. American journal of physiology. Cell physiology. 297 [PubMed]

References and models that cite this paper

Barlow BM, Joos B, Trinh AK, Longtin A. (2018). Cooling reverses pathological bifurcations to spontaneous firing caused by mild traumatic injury. Chaos (Woodbury, N.Y.). 28 [PubMed]

Barlow BSM, Longtin A, Joós B. (2024). Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment. PLoS computational biology. 20 [PubMed]

García-Grajales JA, Rucabado G, García-Dopico A, Peña JM, Jérusalem A. (2015). Neurite, a finite difference large scale parallel program for the simulation of electrical signal propagation in neurites under mechanical loading. PloS one. 10 [PubMed]

Joos B, Barlow BM, Morris CE. (2018). Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells. Handbook of experimental pharmacology. 246 [PubMed]

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