The two programs CLSRanvier.f and propagation.f simulate the excitability of a myelinated axon with injured nodes of Ranvier. The injury is simulated as the Coupled Left Shift (CLS) of the activation(V) and inactivation(V) (availability) of a fraction of Nav channels.
Model Type: Axon
Cell Type(s): Myelinated neuron; Hodgkin-Huxley neuron
Currents: I Na,t; I K; I K,leak; Na/K pump; I Na, leak
Genes: Nav1.6 SCN8A
Model Concept(s): Action Potential Initiation; Activity Patterns; Pathophysiology; Conduction failure; Sodium pump; Depolarization block; Homeostasis
Simulation Environment: FORTRAN
References:
Boucher PA, Joós B, Morris CE. (2012). Coupled left-shift of Nav channels: modeling the Na?-loading and dysfunctional excitability of damaged axons. Journal of computational neuroscience. 33 [PubMed]