State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)


Thomas EA, Petrou S. (2013). Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin. Epilepsia. 54 [PubMed]

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References and models cited by this paper

Adler EM, Yaari Y, David G, Selzer ME. (1986). Frequency-dependent action of phenytoin on lamprey spinal axons. Brain research. 362 [PubMed]

Ayala GF, Lin S, Johnston D. (1977). The mechanism of action of diphenylhydantoin or invertebrate neurons. I. Effects on basic membrane properties. Brain research. 121 [PubMed]

Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ. (2001). Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience. 107 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Dudek FE, Sutula TP. (2007). Epileptogenesis in the dentate gyrus: a critical perspective. Progress in brain research. 163 [PubMed]

Dyhrfjeld-Johnsen J et al. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. Journal of neurophysiology. 97 [PubMed]

Escayg A, Goldin AL. (2010). Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia. 51 [PubMed]

Fellous JM, Rudolph M, Destexhe A, Sejnowski TJ. (2003). Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity. Neuroscience. 122 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Heinemann U et al. (1992). The dentate gyrus as a regulated gate for the propagation of epileptiform activity. Epilepsy research. Supplement. 7 [PubMed]

Hille B. (2001). Ionic Channels of Excitable Membranes.

Hines ML, Carnevale NT. (2006). The NEURON Book.

Howard AL, Neu A, Morgan RJ, Echegoyen JC, Soltesz I. (2007). Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network. Journal of neurophysiology. 97 [PubMed]

Johnston D, Sms WU. (1994). Foundations of cellular neurophysiology.

Kuo CC, Bean BP. (1994). Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Molecular pharmacology. 46 [PubMed]

Kuo CC, Chen RS, Lu L, Chen RC. (1997). Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications. Molecular pharmacology. 51 [PubMed]

Lerman P. (1986). Seizures induced or aggravated by anticonvulsants. Epilepsia. 27 [PubMed]

Liu L et al. (2006). The mechanism of carbamazepine aggravation of absence seizures. The Journal of pharmacology and experimental therapeutics. 319 [PubMed]

Lothman EW, Stringer JL, Bertram EH. (1992). The dentate gyrus as a control point for seizures in the hippocampus and beyond. Epilepsy research. Supplement. 7 [PubMed]

Lytton WW. (2008). Computer modelling of epilepsy. Nature reviews. Neuroscience. 9 [PubMed]

McLean MJ, Macdonald RL. (1983). Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. The Journal of pharmacology and experimental therapeutics. 227 [PubMed]

Meisler MH, Kearney JA. (2005). Sodium channel mutations in epilepsy and other neurological disorders. The Journal of clinical investigation. 115 [PubMed]

Morgan RJ, Soltesz I. (2008). Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Nardi A, Damann N, Hertrampf T, Kless A. (2012). Advances in targeting voltage-gated sodium channels with small molecules. ChemMedChem. 7 [PubMed]

Patlak J. (1991). Molecular kinetics of voltage-dependent Na+ channels. Physiological reviews. 71 [PubMed]

Perucca E, Gram L, Avanzini G, Dulac O. (1998). Antiepileptic drugs as a cause of worsening seizures. Epilepsia. 39 [PubMed]

Quilichini PP et al. (2003). Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro. Epilepsia. 44 [PubMed]

Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. Journal of neurophysiology. 93 [PubMed]

Sherwin AL, Wisen AA, Sokolowski CD. (1973). Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma. Archives of neurology. 29 [PubMed]

Staley KJ, Otis TS, Mody I. (1992). Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. Journal of neurophysiology. 67 [PubMed]

Strandjord RE, Johannessen SI. (1980). Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect. Epilepsia. 21 [PubMed]

Stringer JL, Lothman EW. (1992). Bilateral maximal dentate activation is critical for the appearance of an afterdischarge in the dentate gyrus. Neuroscience. 46 [PubMed]

Thomas EA, Petrou S. (2008). Case for realistic modeling in understanding seizures. Expert review of neurotherapeutics. 8 [PubMed]

Thomas EA, Reid CA, Berkovic SF, Petrou S. (2009). Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels. Archives of neurology. 66 [PubMed]

Thomas EA, Reid CA, Petrou S. (2010). Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia. 51 [PubMed]

Thomas EA, Xu R, Petrou S. (2007). Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience. 147 [PubMed]

References and models that cite this paper

Morris G et al. (2017). Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

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