"… Convergence of multiple kinase activities to induce L-LTP helps to generate a threshold whereby the amount of L-LTP varies steeply with the number of brief (tetanic) electrical stimuli. The model simulates tetanic, -burst, pairing-induced, and chemical L-LTP, as well as L-LTP due to synaptic tagging. The model also simulates inhibition of L-LTP by inhibition of MAPK, CAMKII, PKA, or CAMKIV. The model predicts results of experiments to delineate mechanisms underlying L-LTP induction and expression. …"
Model Type: Synapse; Molecular Network
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Receptors: NMDA
Transmitters: Glutamate
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; CREB
Simulation Environment: Java
Implementer(s): Byrne, John [john.h.byrne at uth.tmc.edu]; Smolen, Paul [paul.d.smolen at uth.tmc.edu]
References:
Smolen P, Baxter DA, Byrne JH. (2006). A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophysical journal. 90 [PubMed]