Abraham WC, Logan B, Greenwood JM, Dragunow M. (2002). Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Agell N, Bachs O, Rocamora N, Villalonga P. (2002). Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cellular signalling. 14 [PubMed]
Ahmed T, Frey JU. (2005). Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro. Neuropharmacology. 49 [PubMed]
Ajay SM, Bhalla US. (2004). A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. The European journal of neuroscience. 20 [PubMed]
Atkins CM, Davare MA, Oh MC, Derkach V, Soderling TR. (2005). Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]
Atkins CM, Nozaki N, Shigeri Y, Soderling TR. (2004). Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]
Auer RN, Jensen ML, Whishaw IQ. (1989). Neurobehavioral deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 9 [PubMed]
Bacskai BJ et al. (1993). Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (New York, N.Y.). 260 [PubMed]
Banko JL, Hou L, Klann E. (2004). NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1. Journal of neurochemistry. 91 [PubMed]
Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. (1998). Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]
Barco A, Alarcon JM, Kandel ER. (2002). Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell. 108 [PubMed]
Beck JV, Arnold KJ. (1977). Parameter Estimation in Engineering and Science. 17-24
Bhalla US. (2002). Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways. Biophysical journal. 83 [PubMed]
Bhalla US, Iyengar R. (1999). Emergent properties of networks of biological signaling pathways. Science (New York, N.Y.). 283 [PubMed]
Blitzer RD, Iyengar R, Landau EM. (2005). Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity. Biological psychiatry. 57 [PubMed]
Bozon B et al. (2003). MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 358 [PubMed]
Bradshaw JM, Kubota Y, Meyer T, Schulman H. (2003). An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]
Bradshaw KD, Emptage NJ, Bliss TV. (2003). A role for dendritic protein synthesis in hippocampal late LTP. The European journal of neuroscience. 18 [PubMed]
Burrone J, Murthy VN. (2003). Synaptic gain control and homeostasis. Current opinion in neurobiology. 13 [PubMed]
Cammalleri M et al. (2003). Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]
Chen HX, Otmakhov N, Strack S, Colbran RJ, Lisman JE. (2001). Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP? Journal of neurophysiology. 85 [PubMed]
Chetkovich DM, Gray R, Johnston D, Sweatt JD. (1991). N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 88 [PubMed]
Cowan DT, Allan L, Griffiths P. (2002). A pilot study into the problematic use of opioid analgesics in chronic non-cancer pain patients. International journal of nursing studies. 39 [PubMed]
Crino P et al. (1998). Presence and phosphorylation of transcription factors in developing dendrites. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]
Davies SP, Reddy H, Caivano M, Cohen P. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal. 351 [PubMed]
Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S. (2000). The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]
Duffy SN, Nguyen PV. (2003). Postsynaptic application of a peptide inhibitor of cAMP-dependent protein kinase blocks expression of long-lasting synaptic potentiation in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]
Dugan LL et al. (1999). Differential effects of cAMP in neurons and astrocytes. Role of B-raf. The Journal of biological chemistry. 274 [PubMed]
Døskeland SO, Ogreid D. (1981). Binding proteins for cyclic AMP in mammalian tissues. The International journal of biochemistry. 13 [PubMed]
Ehlers MD. (2003). Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nature neuroscience. 6 [PubMed]
English JD, Sweatt JD. (1997). A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. The Journal of biological chemistry. 272 [PubMed]
Fonseca R, Nägerl UV, Morris RG, Bonhoeffer T. (2004). Competing for memory: hippocampal LTP under regimes of reduced protein synthesis. Neuron. 44 [PubMed]
Frank PM. (1978). Introduction to System Sensitivity Theory.
Frey U, Huang YY, Kandel ER. (1993). Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science (New York, N.Y.). 260 [PubMed]
Frey U, Morris RG. (1997). Synaptic tagging and long-term potentiation. Nature. 385 [PubMed]
Frey U, Morris RG. (1998). Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP. Neuropharmacology. 37 [PubMed]
Frödin M, Gammeltoft S. (1999). Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Molecular and cellular endocrinology. 151 [PubMed]
Gong B et al. (2004). Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. The Journal of clinical investigation. 114 [PubMed]
Grewal SS et al. (2000). Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. The Journal of biological chemistry. 275 [PubMed]
Guzowski JF et al. (2000). Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]
Hayer A, Bhalla US. (2005). Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS computational biology. 1 [PubMed]
Herberg FW, Taylor SS, Dostmann WR. (1996). Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry. 35 [PubMed]
Hevroni D et al. (1998). Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. Journal of molecular neuroscience : MN. 10 [PubMed]
Horn D, Levy N, Ruppin E. (1998). Memory maintenance via neuronal regulation. Neural computation. 10 [PubMed]
Huang CY, Ferrell JE. (1996). Ultrasensitivity in the mitogen-activated protein kinase cascade. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]
Huang YY, Pittenger C, Kandel ER. (2004). A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proceedings of the National Academy of Sciences of the United States of America. 101 [PubMed]
Hyrc K, Rzeszotnik Z, Kennedy BR. (2005). Why do low and high affinity calcium indicators report cytosolic Ca21 concentrations differently in NMDA but not in AMPAstimulated neurons? Soc Neurosci Abstr 467.5.
Iida N et al. (2001). Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]
Impey S et al. (2002). Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron. 34 [PubMed]
Impey S et al. (1998). Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron. 21 [PubMed]
Ismailov I, Kalikulov D, Inoue T, Friedlander MJ. (2004). The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]
Jones MW et al. (2001). A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nature neuroscience. 4 [PubMed]
Kang H et al. (2001). An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell. 106 [PubMed]
Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. (2004). Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. The Journal of cell biology. 164 [PubMed]
Karpova A, Sanna PP, Behnisch T. (2006). Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression. Neuroscience. 137 [PubMed]
Kawasaki H et al. (1998). A family of cAMP-binding proteins that directly activate Rap1. Science (New York, N.Y.). 282 [PubMed]
Kelleher RJ, Govindarajan A, Jung HY, Kang H, Tonegawa S. (2004). Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 116 [PubMed]
Khan A, Pepio AM, Sossin WS. (2001). Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]
Kikuchi S et al. (2003). Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling of protein phosphatase 2A. Neural networks : the official journal of the International Neural Network Society. 16 [PubMed]
Komiyama NH et al. (2002). SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Le Good JA et al. (1998). Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science (New York, N.Y.). 281 [PubMed]
Lengyel I et al. (2004). Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus. The European journal of neuroscience. 20 [PubMed]
Li YX, Zhang Y, Lester HA, Schuman EM, Davidson N. (1998). Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]
Lisman JE, Zhabotinsky AM. (2001). A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly. Neuron. 31 [PubMed]
Liu J, Fukunaga K, Yamamoto H, Nishi K, Miyamoto E. (1999). Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]
Lynch MA. (2004). Long-term potentiation and memory. Physiological reviews. 84 [PubMed]
Malenka RC, Lancaster B, Zucker RS. (1992). Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation. Neuron. 9 [PubMed]
Martin KA, Toker A, Romanelli A, Blenis J. (1999). p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol Cell Biol. 19
Martin KC. (2002). Synaptic tagging during synapse-specific long-term facilitation of Aplysia sensory-motor neurons. Neurobiology of learning and memory. 78 [PubMed]
Martin KC et al. (1997). MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron. 18 [PubMed]
Mauelshagen J, Parker GR, Carew TJ. (1996). Dynamics of induction and expression of long-term synaptic facilitation in Aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]
Michael D et al. (1998). Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]
Morozov A et al. (2003). Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron. 39 [PubMed]
Müller U, Carew TJ. (1998). Serotonin induces temporally and mechanistically distinct phases of persistent PKA activity in Aplysia sensory neurons. Neuron. 21 [PubMed]
Nguyen PV, Abel T, Kandel ER. (1994). Requirement of a critical period of transcription for induction of a late phase of LTP. Science (New York, N.Y.). 265 [PubMed]
Nguyen PV, Kandel ER. (1996). A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]
Otmakhov N, Griffith LC, Lisman JE. (1997). Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of pairing-induced long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]
Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB. (1997). Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]
Patterson SL et al. (2001). Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron. 32 [PubMed]
Pettigrew DB, Smolen P, Baxter DA, Byrne JH. (2005). Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in aplysia. Journal of computational neuroscience. 18 [PubMed]
Pittenger C, Kandel ER. (2003). In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 358 [PubMed]
Pokorska A et al. (2003). Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons. Journal of neurochemistry. 84 [PubMed]
Pologruto TA, Yasuda R, Svoboda K. (2004). Monitoring neural activity and [Ca2+] with genetically encoded Ca2+ indicators. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]
Press WH, Teukolsky SA, Vetterling WT, Flannery BP. (1992). Numerical Recipes in Fortran 77: The Art of Scientific Computing.
Rakhit S, Clark CJ, O'shaughnessy CT, Morris BJ. (2005). N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase, mitogen- and stress-activated kinase, and ribosomal s6 kinase phosphorylation in cortical neurons. Molecular pharmacology. 67 [PubMed]
Raser JM, O'Shea EK. (2005). Noise in gene expression: origins, consequences, and control. Science (New York, N.Y.). 309 [PubMed]
Roberson ED, Sweatt JD. (1996). Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. The Journal of biological chemistry. 271 [PubMed]
Rosenblum K et al. (2002). The role of extracellular regulated kinases I/II in late-phase long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Sacktor TC et al. (2003). Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem. 278
Sanna PP et al. (2002). Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Schmitt JM, Guire ES, Saneyoshi T, Soderling TR. (2005). Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]
Takei N et al. (2004). Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]
Tsien JZ, Huerta PT, Tonegawa S. (1996). The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 87 [PubMed]
Tsokas P et al. (2005). Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]
Vincent P, Brusciano D. (2001). Cyclic AMP imaging in neurones in brain slice preparations. Journal of neuroscience methods. 108 [PubMed]
Waltereit R et al. (2001). Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]
Wang H et al. (2003). Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]
Wittenberg GM, Sullivan MR, Tsien JZ. (2002). Synaptic reentry reinforcement based network model for long-term memory consolidation. Hippocampus. 12 [PubMed]
Wong ST et al. (1999). Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron. 23 [PubMed]
Woo NH, Duffy SN, Abel T, Nguyen PV. (2000). Genetic and pharmacological demonstration of differential recruitment of cAMP-dependent protein kinases by synaptic activity. Journal of neurophysiology. 84 [PubMed]
Wu GY, Deisseroth K, Tsien RW. (2001). Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proceedings of the National Academy of Sciences of the United States of America. 98 [PubMed]
Wu SP, Lu KT, Chang WC, Gean PW. (1999). Involvement of mitogen-activated protein kinase in hippocampal long-term potentiation. Journal of biomedical science. 6 [PubMed]
Yang L et al. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]
Ying SW et al. (2002). Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Zhang HT et al. (2004). Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 29 [PubMed]
Zola-Morgan S, Squire LR, Amaral DG. (1986). Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 6 [PubMed]
Antunes G, Simoes-de-Souza FM. (2018). AMPA receptor trafficking and its role in heterosynaptic plasticity. Scientific reports. 8 [PubMed]
Bhalla US. (2017). Synaptic input sequence discrimination on behavioral timescales mediated by reaction-diffusion chemistry in dendrites. eLife. 6 [PubMed]
Clopath C, Ziegler L, Vasilaki E, Büsing L, Gerstner W. (2008). Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. PLoS computational biology. 4 [PubMed]
Fridlyand LE, Philipson LH. (2016). Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PloS one. 11 [PubMed]
Kastellakis G, Silva AJ, Poirazi P. (2016). Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell reports. 17 [PubMed]
Liu RY et al. (2013). Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]
Manninen T, Hituri K, Kotaleski JH, Blackwell KT, Linne ML. (2010). Postsynaptic signal transduction models for long-term potentiation and depression. Frontiers in computational neuroscience. 4 [PubMed]