Aguiar P, Sousa M, Lima D. (2010). NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons. Journal of neurophysiology. 104 [PubMed]
Al-Kaisy A et al. (2014). Sustained effectiveness of 10 kHz high-frequency spinal cord stimulation for patients with chronic, low back pain: 24-month results of a prospective multicenter study. Pain medicine (Malden, Mass.). 15 [PubMed]
Alvarez FJ, Kavookjian AM, Light AR. (1993). Ultrastructural morphology, synaptic relationships, and CGRP immunoreactivity of physiologically identified C-fiber terminals in the monkey spinal cord. The Journal of comparative neurology. 329 [PubMed]
Baba H et al. (2003). Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Molecular and cellular neurosciences. 24 [PubMed]
Baba H, Yoshimura M, Nishi S, Shimoji K. (1994). Synaptic responses of substantia gelatinosa neurones to dorsal column stimulation in rat spinal cord in vitro. The Journal of physiology. 478 ( Pt 1) [PubMed]
Barchini J et al. (2012). Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy. Neuroscience. 215 [PubMed]
Blomqvist A, Craig AD. (2000). Is neuropathic pain caused by the activation of nociceptive-specific neurons due to anatomic sprouting in the dorsal horn? The Journal of comparative neurology. 428 [PubMed]
Boulenguez P et al. (2010). Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nature medicine. 16 [PubMed]
Britton NF, Chaplain MA, Skevington SM. (1996). The role of N-methyl-D-aspartate (NMDA) receptors in wind-up: a mathematical model. IMA journal of mathematics applied in medicine and biology. 13 [PubMed]
Britton NF, Skevington SM. (1996). On the mathematical modelling of pain. Neurochemical research. 21 [PubMed]
Cameron T. (2004). Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. Journal of neurosurgery. 100 [PubMed]
Campbell JN, Meyer RA. (2006). Mechanisms of neuropathic pain. Neuron. 52 [PubMed]
Carlton SM, Westlund KN, Zhang D, Willis WD. (1992). GABA-immunoreactive terminals synapse on primate spinothalamic tract cells. The Journal of comparative neurology. 322 [PubMed]
Chung JM, Fang ZR, Hori Y, Lee KH, Willis WD. (1984). Prolonged inhibition of primate spinothalamic tract cells by peripheral nerve stimulation. Pain. 19 [PubMed]
Chung JM, Lee KH, Hori Y, Endo K, Willis WD. (1984). Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells. Pain. 19 [PubMed]
Costigan M, Scholz J, Woolf CJ. (2009). Neuropathic pain: a maladaptive response of the nervous system to damage. Annual review of neuroscience. 32 [PubMed]
Coull JA et al. (2005). BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 438 [PubMed]
Coull JA et al. (2003). Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 424 [PubMed]
Cui JG, Linderoth B, Meyerson BA. (1996). Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat. Pain. 66 [PubMed]
Cui JG, Meyerson BA, Sollevi A, Linderoth B. (1998). Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation. Neuroscience letters. 247 [PubMed]
Drew GM, Siddall PJ, Duggan AW. (2004). Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. Pain. 109 [PubMed]
Dubuisson D. (1989). Effect of dorsal-column stimulation on gelatinosa and marginal neurons of cat spinal cord. Journal of neurosurgery. 70 [PubMed]
Duggan AW, Foong FW. (1985). Bicuculline and spinal inhibition produced by dorsal column stimulation in the cat. Pain. 22 [PubMed]
Fields HL, Malick A, Burstein R. (1995). Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. Journal of neurophysiology. 74 [PubMed]
Foreman RD, Beall JE, Coulter JD, Willis WD. (1976). Effects of dorsal column stimulation on primate spinothalamic tract neurons. Journal of neurophysiology. 39 [PubMed]
Freeman TB, Campbell JN, Long DM. (1983). Naloxone does not affect pain relief induced by electrical stimulation in man. Pain. 17 [PubMed]
Giesler GJ, Gerhart KD, Yezierski RP, Wilcox TK, Willis WD. (1981). Postsynaptic inhibition of primate spinothalamic neurons by stimulation in nucleus raphe magnus. Brain research. 204 [PubMed]
Grill WM, Zhang TC, Janik JJ. (2013). Network model of the effects of spinal cord stimulation 6th International IEEE-EMBS Conference on Neural Engineering.
Guan Y. (2012). Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action. Current pain and headache reports. 16 [PubMed]
Handwerker HO, Anton F, Reeh PW. (1987). Discharge patterns of afferent cutaneous nerve fibers from the rat's tail during prolonged noxious mechanical stimulation. Experimental brain research. 65 [PubMed]
Harper AA, Lawson SN. (1985). Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. The Journal of physiology. 359 [PubMed]
Heinricher MM, Tavares I, Leith JL, Lumb BM. (2009). Descending control of nociception: Specificity, recruitment and plasticity. Brain research reviews. 60 [PubMed]
Herrero JF, Laird JM, López-García JA. (2000). Wind-up of spinal cord neurones and pain sensation: much ado about something? Progress in neurobiology. 61 [PubMed]
Hillman P, Wall PD. (1969). Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells. Experimental brain research. 9 [PubMed]
Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]
IGGO A. (1958). The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. The Journal of physiology. 142 [PubMed]
Janssen SP et al. (2012). Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition. Neurochemistry international. 60 [PubMed]
Jones EG, Willis WD, Lenz FA, Casey KL. (2010). The Human Pain System: Experimental and Clinical Perspectives.
Kajander KC, Bennett GJ. (1992). Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. Journal of neurophysiology. 68 [PubMed]
Kato G, Kosugi M, Mizuno M, Strassman AM. (2011). Separate inhibitory and excitatory components underlying receptive field organization in superficial medullary dorsal horn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]
Keller AF, Beggs S, Salter MW, De Koninck Y. (2007). Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Molecular pain. 3 [PubMed]
Kumar K et al. (2007). Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome. Pain. 132 [PubMed]
Lavertu G, Côté SL, De Koninck Y. (2014). Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain : a journal of neurology. 137 [PubMed]
Le Franc Y, Le Masson G. (2010). Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. Journal of neurophysiology. 104 [PubMed]
Lekan HA, Carlton SM. (1995). Glutamatergic and GABAergic input to rat spinothalamic tract cells in the superficial dorsal horn. The Journal of comparative neurology. 361 [PubMed]
Liu X, Eschenfelder S, Blenk KH, Jänig W, Häbler H. (2000). Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. Pain. 84 [PubMed]
Lu Y, Perl ER. (2003). A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]
Lu Y, Perl ER. (2005). Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]
MENDELL LM, WALL PD. (1965). RESPONSES OF SINGLE DORSAL CORD CELLS TO PERIPHERAL CUTANEOUS UNMYELINATED FIBRES. Nature. 206 [PubMed]
Maeda Y, Wacnik PW, Sluka KA. (2008). Low frequencies, but not high frequencies of bi-polar spinal cord stimulation reduce cutaneous and muscle hyperalgesia induced by nerve injury. Pain. 138 [PubMed]
Melnick IV, Santos SF, Safronov BV. (2004). Mechanism of spike frequency adaptation in substantia gelatinosa neurones of rat. The Journal of physiology. 559 [PubMed]
Melnick IV, Santos SF, Szokol K, Szûcs P, Safronov BV. (2004). Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat. Journal of neurophysiology. 91 [PubMed]
Melzack R, Wall PD. (1965). Pain mechanisms: a new theory. Science (New York, N.Y.). 150 [PubMed]
Mendell LM. (1966). Physiological properties of unmyelinated fiber projection to the spinal cord. Experimental neurology. 16 [PubMed]
Menétrey D, Giesler GJ, Besson JM. (1977). An analysis of response properties of spinal cord dorsal horn neurones to nonnoxious and noxious stimuli in the spinal rat. Experimental brain research. 27 [PubMed]
Meyerson BA, Linderoth B, Foreman RD. (2009). Mechanisms of action of spinal cord stimulation Textbook of Stereotactic and Functional Neurosurgery..
Moore KA et al. (2002). Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]
Morisset V, Nagy F. (1999). Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]
Morisset V, Nagy F. (2000). Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons. The European journal of neuroscience. 12 [PubMed]
North RB, Kidd DH, Zahurak M, James CS, Long DM. (1993). Spinal cord stimulation for chronic, intractable pain: experience over two decades. Neurosurgery. 32 [PubMed]
Oakley JC, Prager JP. (2002). Spinal cord stimulation: mechanisms of action. Spine. 27 [PubMed]
Polgár E, Al Ghamdi KS, Todd AJ. (2010). Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input. Neuroscience. 167 [PubMed]
Prescott SA, De Koninck Y. (2002). Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. The Journal of physiology. 539 [PubMed]
Prescott SA, De Koninck Y. (2005). Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]
Prescott SA, Ratté S. (2012). Pain processing by spinal microcircuits: afferent combinatorics. Current opinion in neurobiology. 22 [PubMed]
Price DD, Hull CD, Buchwald NA. (1971). Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli. Experimental neurology. 33 [PubMed]
Ratté S, Hong S, De Schutter E, Prescott SA. (2013). Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer. Neuron. 78 [PubMed]
Ruscheweyh R, Sandkühler J. (2002). Lamina-specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro. The Journal of physiology. 541 [PubMed]
Safronov BV, Wolff M, Vogel W. (1997). Functional distribution of three types of Na+ channel on soma and processes of dorsal horn neurones of rat spinal cord. The Journal of physiology. 503 ( Pt 2) [PubMed]
Safronov BV, Wolff M, Vogel W. (2000). Excitability of the soma in central nervous system neurons. Biophysical journal. 78 [PubMed]
Santos SF, Rebelo S, Derkach VA, Safronov BV. (2007). Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat. The Journal of physiology. 581 [PubMed]
Schouenborg J, Sjölund BH. (1983). Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex. Journal of neurophysiology. 50 [PubMed]
Shealy CN, Mortimer JT, Hagfors NR. (1970). Dorsal column electroanalgesia. Journal of neurosurgery. 32 [PubMed]
Shechter R et al. (2013). Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain. Anesthesiology. 119 [PubMed]
Simone DA et al. (1991). Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. Journal of neurophysiology. 66 [PubMed]
Slugg RM, Meyer RA, Campbell JN. (2000). Response of cutaneous A- and C-fiber nociceptors in the monkey to controlled-force stimuli. Journal of neurophysiology. 83 [PubMed]
Smits H, van Kleef M, Joosten EA. (2012). Spinal cord stimulation of dorsal columns in a rat model of neuropathic pain: evidence for a segmental spinal mechanism of pain relief. Pain. 153 [PubMed]
Song Z, Ansah OB, Meyerson BA, Pertovaara A, Linderoth B. (2013). Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus. Neuroscience. 253 [PubMed]
Song Z, Meyerson BA, Linderoth B. (2011). Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy. Pain. 152 [PubMed]
Stiller CO et al. (1996). Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery. 39 [PubMed]
Szucs P et al. (2013). Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord. The Journal of comparative neurology. 521 [PubMed]
Taylor RS, Desai MJ, Rigoard P, Taylor RJ. (2014). Predictors of pain relief following spinal cord stimulation in chronic back and leg pain and failed back surgery syndrome: a systematic review and meta-regression analysis. Pain practice : the official journal of World Institute of Pain. 14 [PubMed]
Todd AJ. (2010). Neuronal circuitry for pain processing in the dorsal horn. Nature reviews. Neuroscience. 11 [PubMed]
Torsney C. (2011). Inflammatory pain unmasks heterosynaptic facilitation in lamina I neurokinin 1 receptor-expressing neurons in rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]
Torsney C, MacDermott AB. (2006). Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]
Wall PD, Gutnick M. (1974). Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma. Experimental neurology. 43 [PubMed]
Wolff M, Vogel W, Safronov BV. (1998). Uneven distribution of K+ channels in soma, axon and dendrites of rat spinal neurones: functional role of the soma in generation of action potentials. The Journal of physiology. 509 ( Pt 3) [PubMed]
Woolf CJ, King AE. (1987). Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord. Journal of neurophysiology. 58 [PubMed]
Woolf CJ, Wall PD. (1982). Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain research. 242 [PubMed]
Yakhnitsa V, Linderoth B, Meyerson BA. (1999). Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. Pain. 79 [PubMed]
Yasaka T, Tiong SYX, Hughes DI, Riddell JS, Todd AJ. (2010). Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain. 151 [PubMed]
Zheng J, Lu Y, Perl ER. (2010). Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents. The Journal of physiology. 588 [PubMed]
von Hehn CA, Baron R, Woolf CJ. (2012). Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 73 [PubMed]
Gilbert JE, Titus N, Zhang T, Esteller R, Grill WM. (2022). Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement eNeuro. 9 [PubMed]
Medlock L et al. (2022). Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]